|
KMID : 0811820130170010006
|
|
Journal of Korean Society of Pediatric Nephrology
2013 Volume.17 No. 1 p.6 ~ p.12
|
|
|
Pathology of Thrombotic Microangiopathy
|
|
Sol Mee-Young
|
|
|
Abstract
|
|
|
|
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP. Renal biopsy finding of TMA represents kidney involvement of HUS/TTP as well as other diseases such as malignant hypertension, drug toxicity, eclampsia, pre-eclampsia, and several systemic infections. Autoimmune diseases and transplant kidney sometime also have TMA. It is needed to consider a complete autoimmune work-up of patients presenting with TMA including tests for ANA, ANCA, and ADAMTS13 inhibitory antibodies, because there are several reports of association with TMA in patients of SLE, anti-phospholipid syndrome, and ANCA-associated vasculitis.
|
|
|
KEYWORD
|
|
|
Thrombotic microangiopathy, Renal biopsy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|